Aldh3b1 Gene Summary [Rat]
Predicted to enable 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in aldehyde metabolic process. Predicted to act upstream of or within aldehyde catabolic process and cellular response to oxidative stress. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ALDH3B1 (aldehyde dehydrogenase 3 family member B1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldh3b1 |
| Official Name | aldehyde dehydrogenase 3 family, member B1 [Source:RGD Symbol;Acc:1359546] |
| Ensembl ID | ENSRNOG00000017512 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 3 family, member B1 |
| Synonyms | 1700001N19RIK, aldehyde dehydrogenase 3 family member B1, aldehyde dehydrogenase 3 family, member B1, ALDH4, ALDH7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aldh3b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldehyde dehydrogenase family
- Acyl-CoA reductase (LuxC)
- betaine-aldehyde dehydrogenase
- aldehyde dehydrogenase [NAD(P)]
- aldehyde dehydrogenase (NAD)
- 1-pyrroline dehydrogenase
- aldehyde dehydrogenase
- enzyme
- protein binding
- delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative
- delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain)
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
Pathways
Biological processes and signaling networks where the Aldh3b1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- lipid
- trans-2-nonenal
- medium-chain aldehyde
- aldehyde
- hexanal
- octanal
- nonanal
- long-chain aldehyde
- alcohol
- trans-2-octenal
role in cell
- cell death
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Plasma Membrane
- secretory granule membrane
- specific granule membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aldh3b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- aldehyde catabolic process
- response to oxidative stress
- cellular aldehyde metabolic process
- lipid metabolic process
- ethanol catabolic process
- cellular response to oxidative stress
- alcohol metabolic process
- sphingolipid catabolic process
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular vesicular exosome
- cytoplasm
- cytosol
- vesicle
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- aldehyde dehydrogenase (NAD) activity
- 3-chloroallyl aldehyde dehydrogenase activity
- protein binding
- aldehyde dehydrogenase [NAD(P)+] activity
- benzaldehyde dehydrogenase (NADP+) activity
- benzaldehyde dehydrogenase (NAD+) activity