Znhit3 Gene Summary [Rat]
Predicted to enable thyroid hormone receptor binding activity. Predicted to be involved in box C/D snoRNP assembly; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and snoRNA localization. Located in cytoplasm and nucleus. Implicated in PEHO syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | Znhit3 |
| Official Name | zinc finger, HIT-type containing 3 [Source:RGD Symbol;Acc:1598226] |
| Ensembl ID | ENSRNOG00000027818 |
| Bio databases IDs | |
| Aliases | zinc finger, HIT-type containing 3 |
| Synonyms | Hit1, Myohd1, PEHO, TRIP-3, zinc finger, HIT type 3, zinc finger HIT-type containing 3, zinc finger, HIT-type containing 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Znhit3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- zinc finger HIT (zf-HIT) domain
- protein binding
- thyroid hormone receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Znhit3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snoRNA localization
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- box C/D snoRNP assembly
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- pre-snoRNP complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- thyroid hormone receptor binding