Zbtb17 Gene Summary [Rat]
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding activity; and transcription coactivator binding activity. Predicted to be involved in several processes, including negative regulation of cell population proliferation; regulation of cytokine production; and regulation of transcription by RNA polymerase II. Predicted to act upstream of with a negative effect on G1 to G0 transition. Predicted to act upstream of or within ectoderm development; gastrulation with mouth forming second; and positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of protein-DNA complex. Predicted to be active in nucleoplasm. Orthologous to human ZBTB17 (zinc finger and BTB domain containing 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zbtb17 |
| Official Name | zinc finger and BTB domain containing 17 [Source:RGD Symbol;Acc:1307143] |
| Ensembl ID | ENSRNOG00000010436 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 17 |
| Synonyms | AA589413, Lp-1, MIZ-1, mZ13, pHZ-67, Zfp100, zinc finger and BTB domain containing 17, ZNF151, ZNF60 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zbtb17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- amphipathic helix
- nucleic acid binding
- BTB_POZ
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- Myc/p300 binding domain
- DNA binding
- Broad-Complex, Tramtrack and Bric a brac
- double-stranded DNA binding
- Zinc-finger double domain
- BTB/POZ domain
- zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Zbtb17 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- growth failure
- dilated cardiomyopathy
- lung metastasis
- T acute lymphoblastic leukemia
- gastrulation failure
- neuroblastoma
- neuroblastoma formation
- peripheral neuropathy
- precursor B-cell acute lymphoblastic leukemia
role in cell
- differentiation
- proliferation
- expression in
- phosphorylation in
- growth
- apoptosis
- quantity
- cell death
- cell cycle progression
- regulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zbtb17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of cell proliferation
- gastrulation with mouth forming second
- negative regulation of cell cycle
- G1 to G0 transition
- ectoderm development
- regulation of cytokine production
- regulation of immune system process
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- protein-DNA complex
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- core promoter sequence-specific DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- transcription coactivator binding