Pigw Gene Summary [Rat]
Predicted to enable glucosaminyl-phosphatidylinositol O-acyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process and protein localization to plasma membrane. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 5. Orthologous to human PIGW (phosphatidylinositol glycan anchor biosynthesis class W). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pigw |
| Official Name | phosphatidylinositol glycan anchor biosynthesis, class W [Source:RGD Symbol;Acc:727962] |
| Ensembl ID | ENSRNOG00000027857 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol glycan anchor biosynthesis, class W |
| Synonyms | 2610044A17RIK, Gwt1, HPMRS5, phosphatidylinositol glycan anchor biosynthesis class W, phosphatidylinositol glycan anchor biosynthesis, class W |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pigw often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GWT1
- enzyme
- O-acyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pigw gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- GPI anchor metabolic process
- GPI anchor biosynthetic process
- preassembly of GPI anchor in ER membrane
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- O-acyltransferase activity
- glucosaminyl-phosphotidylinositol O-acyltransferase activity