Tspan15 Gene Summary [Rat]
Predicted to enable enzyme binding activity. Predicted to be involved in several processes, including negative regulation of Notch signaling pathway; protein localization to plasma membrane; and regulation of membrane protein ectodomain proteolysis. Predicted to be located in several cellular components, including cell surface; nuclear body; and tetraspanin-enriched microdomain. Predicted to be active in plasma membrane. Orthologous to human TSPAN15 (tetraspanin 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tspan15 |
| Official Name | tetraspanin 15 [Source:RGD Symbol;Acc:1588304] |
| Ensembl ID | ENSRNOG00000046204 |
| Bio databases IDs | |
| Aliases | tetraspanin 15 |
| Synonyms | 1110036D12RIK, 2700063A19Rik, NET-7, tetraspanin 15, TM4SF15 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tspan15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- breast cancer
- pulmonary embolism
- pulmonary infarction
- venous thromboembolism
- deep vein thrombosis
- thromboembolism
- early missed abortion
- heart disease
role in cell
- expression in
- transmigration
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- tetraspanin-enriched microdomain
- cell junction
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- cytosol
- endoplasmic reticulum lumen
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tspan15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Notch signaling pathway
- regulation of membrane protein ectodomain proteolysis
- protein maturation
- negative regulation of Notch signaling pathway
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- endoplasmic reticulum lumen
- nuclear body
- intracellular membrane-bounded organelle
- cell junction
- cytosol
- plasma membrane
- tetraspanin-enriched microdomain
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme binding