Slc7a1 Gene Summary [Rat]
Enables L-arginine transmembrane transporter activity. Involved in L-arginine import across plasma membrane; L-arginine transmembrane transport; and regulation of TOR signaling. Located in apical plasma membrane and basal plasma membrane. Orthologous to human SLC7A1 (solute carrier family 7 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc7a1 |
| Official Name | solute carrier family 7 member 1 [Source:RGD Symbol;Acc:3716] |
| Ensembl ID | ENSRNOG00000000924 |
| Bio databases IDs | |
| Aliases | solute carrier family 7 member 1 |
| Synonyms | 4831426K01RIK, ATRC1, CAT-1, EcoR, ER, ERR, HCAT1, LOC102724249, mCAT-1, Rec-1, REC1L, Rev-1, solute carrier family 7 (cationic amino acid transporter, y+ system), member 1, solute carrier family 7 member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc7a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- viral receptor
- L-amino acid transporter
- basic amino acid transporter
- protein binding
- histidine transporter
- cationic amino acid transport permease
- organic cation transporter
- amino acid permease (GABA permease)
- lysine transporter
- amino acid permease
- ornithine transporter
- L-type amino acid transporter
- C-terminus of AA_permease
- amino acid transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc7a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- prostate cancer
- uterine leiomyoma
- leiomyomatosis
- breast carcinoma
- aldosterone producing adrenocortical adenoma
- adenoma formation
- cardiovascular disorder
- major depression
- anemia
regulates
- nitric oxide
- reporter mRNA
- L-lysine
- L-ornithine
- Mir122a/b
- L-arginine
- SLC7A1
- arginine
- basic amino acid
- amino acids
role in cell
- differentiation
- proliferation
- migration
- invasion by
- number
- cell viability
- colony formation by
- abnormal morphology
- function
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- granules
- apical membrane
- basolateral membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc7a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- lysine transport
- L-amino acid transport
- positive regulation of T cell proliferation
- amino acid transport
- ornithine transport
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- membrane
- macromolecular complex
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- L-lysine transmembrane transporter activity
- L-ornithine transmembrane transporter activity
- L-histidine transmembrane transporter activity
- basic amino acid transmembrane transporter activity
- amino acid transmembrane transporter activity
- viral receptor activity