Top3b Gene Summary [Rat]
Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity and RNA topoisomerase activity. Predicted to be involved in DNA recombination; DNA repair; and DNA topological change. Predicted to act upstream of or within chromosome segregation. Predicted to be located in condensed chromosome. Predicted to be part of DNA topoisomerase III-beta-TDRD3 complex. Predicted to be active in nucleus. Orthologous to human TOP3B (DNA topoisomerase III beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Top3b |
| Official Name | DNA topoisomerase III beta [Source:RGD Symbol;Acc:1309468] |
| Ensembl ID | ENSRNOG00000001845 |
| Bio databases IDs | |
| Aliases | DNA topoisomerase III beta |
| Synonyms | DNA topoisomerase III beta, DNA topoisomerase III β, TOP3B1, TOP3 β, TOPO3, Topo III β, topoisomerase (DNA) III beta, topoisomerase (DNA) III β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Top3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA topoisomerase type I
- Bacterial DNA topoisomeraes I ATP-binding domain
- Bacterial DNA topoisomerase I DNA-binding domain
- DNA topoisomerase
- TOP1Ac
- TOPRIM
- isomerase
- Toprim domain
- topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins
- enzyme
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Top3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA recombination
- chromosome segregation
- DNA topological change
Cellular Component
Where in the cell the gene product is active
- condensed chromosome
- nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- DNA topoisomerase activity
- DNA topoisomerase type I activity