Ccdc66 Gene Summary [Rat]
Predicted to enable microtubule binding activity and protein homodimerization activity. Predicted to be involved in several processes, including ciliary transition zone assembly; detection of light stimulus involved in visual perception; and microtubule cytoskeleton organization. Predicted to be located in several cellular components, including Flemming body; cytoskeleton; and cytosol. Predicted to be active in cilium; microtubule; and photoreceptor inner segment. Orthologous to human CCDC66 (coiled-coil domain containing 66). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccdc66 |
| Official Name | coiled-coil domain containing 66 [Source:RGD Symbol;Acc:1560873] |
| Ensembl ID | ENSRNOG00000028380 |
| Bio databases IDs | |
| Aliases | coiled-coil domain containing 66 |
| Synonyms | coiled-coil domain containing 66, E230015L20Rik, RGD1560873 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccdc66 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- protein homodimerization
- protein binding
- Coiled-coil domain-containing protein 66
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- liver cancer
- epithelial cancer
- epithelial neoplasia
- acute myeloid leukemia
- nephrosis
- cholangiocarcinoma cancer
- bile duct cancer
- liver neoplasia
- biliary tract cancer
regulated by
regulates
- BBSome
- CEP290
role in cell
- formation
- length
- assembly
- organization
- cytokinesis in
- nucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- intracellular membrane-bounded organelle
- spindle apparatus
- centriolar satellite
- cilia
- Plasma Membrane
- basal bodies
- centrosome
- centriole
- microtubules
- axonemes
- midbody
- Flemming body
- cytosol
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccdc66 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retina homeostasis
- detection of light stimulus involved in visual perception
- microtubule bundle formation
- cilium morphogenesis
Cellular Component
Where in the cell the gene product is active
- centrosome
- cilium basal body
- centriolar satellite
- cilium
- cytosol
- cell junction
- ciliary transition zone
- photoreceptor inner segment
- photoreceptor outer segment
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- microtubule binding