Poc1a Gene Summary [Rat]
Predicted to be involved in cilium assembly. Predicted to act upstream of or within several processes, including growth plate cartilage chondrocyte development; non-motile cilium assembly; and positive regulation of centrosome duplication. Predicted to be located in centrosome; cytoplasm; and spindle pole. Predicted to be active in centriole and ciliary basal body. Orthologous to human POC1A (POC1 centriolar protein A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Poc1a |
| Official Name | POC1 centriolar protein A [Source:RGD Symbol;Acc:1565004] |
| Ensembl ID | ENSRNOG00000037295 |
| Bio databases IDs | |
| Aliases | POC1 centriolar protein A |
| Synonyms | 2510040D07Rik, cha, DKFZp434C245, PIX2, POC1 centriolar protein A, RGD1565004, SOFT, WDR51A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Poc1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- WD40 repeats
- peptidase
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- non-insulin-dependent diabetes mellitus
- short stature, onychodysplasia, facial dysmorphism, and hypotrichosis
- isolated growth hormone deficiency type Ia
- diabetes mellitus
- kidney stones
role in cell
- organization
- assembly
- duplication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal bodies
- centrosome
- centriole
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Poc1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
Cellular Component
Where in the cell the gene product is active
- centrosome
- centriole
- cytoplasm
- cilium basal body
- spindle pole
Molecular Function
What the gene product does at the molecular level
- protein binding