Hmcn1 Gene Summary [Rat]
Predicted to enable axon guidance receptor activity. Predicted to be involved in several processes, including actin cytoskeleton organization; basement membrane organization; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within response to bacterium. Predicted to be located in several cellular components, including basement membrane; cell cortex; and muscle tendon junction. Predicted to be active in axon; neuronal cell body; and plasma membrane. Human ortholog(s) of this gene implicated in age related macular degeneration 1. Orthologous to human HMCN1 (hemicentin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmcn1 |
| Official Name | hemicentin 1 [Source:RGD Symbol;Acc:1564772] |
| Ensembl ID | ENSRNOG00000028627 |
| Bio databases IDs | |
| Aliases | hemicentin 1 |
| Synonyms | ARMD1, AXPC1, EG545370, FBLN6, FIBL-6, Gm201, HEMICENTIN-1, RGD1564772 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hmcn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Immunoglobulin C1-set domain
- Complement Clr-like EGF-like
- von Willebrand factor (vWF) type A domain
- immunoglobulin domain
- Human growth factor-like EGF
- Immunoglobulin I-set domain
- von Willebrand factor type A domain
- nidG2
- protein binding
- T-cell surface glycoprotein CD3 delta chain
- EGF_CA
- vWFA
- Immunoglobulin like
- EGF domain
- Spondin-like TSP1 domain
- Immunoglobulin V-set domain
- Coagulation Factor Xa inhibitory site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- age-related macular degeneration
- age-related macular degeneration type 1
- chronic obstructive pulmonary disease
- late-onset Alzheimer disease
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
role in cell
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell junction
- extracellular vesicles
- Cytoplasm
- cell cortex
- extracellular matrix
- cell-matrix adherens junctions
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hmcn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- response to bacterium
- heterophilic cell-cell adhesion
- basement membrane organization
- homophilic cell adhesion
- visual perception
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- adherens junction
- basement membrane
- extracellular vesicular exosome
- cleavage furrow
- cytoplasm
- cell cortex
- muscle tendon junction
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- extracellular matrix structural constituent