Wdr19 Gene Summary [Rat]
Predicted to be involved in cilium organization; protein localization to ciliary membrane; and protein-containing complex assembly. Predicted to act upstream of or within several processes, including chordate embryonic development; embryonic organ development; and myotome development. Predicted to be located in motile cilium and photoreceptor connecting cilium. Predicted to be part of intraciliary transport particle A. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in several diseases, including Caroli disease; Senior-Loken syndrome; asphyxiating thoracic dystrophy 5; cranioectodermal dysplasia 4; and nephronophthisis 13. Orthologous to human WDR19 (WD repeat domain 19). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr19 |
| Official Name | WD repeat domain 19 [Source:RGD Symbol;Acc:1306997] |
| Ensembl ID | ENSRNOG00000002932 |
| Bio databases IDs | |
| Aliases | WD repeat domain 19 |
| Synonyms | ATD5, C330027H04RIK, CED4, CFAP66, D330023L08Rik, DYF-2, FAP66, IFT144, KIAA1638, mKIAA1638, NPHP13, ORF26, Oseg6, PWDMP, RGD1306997, SPGF72, SRTD5, WD repeat domain 19 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wdr19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD domain, G-beta repeat
- WD40
- protein binding
- Double zinc ribbon
Pathways
Biological processes and signaling networks where the Wdr19 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Senior-Loken syndrome 8
- Jeune syndrome
- short-rib thoracic dysplasia type 5 without polydactyly
- spermatogenic failure 72
- breast cancer
- retinal dystrophy
- WDR19-related disorder
- nephronophthisis type 13
- cranioectodermal dysplasia type 4
- Leber congenital amaurosis type 1
regulated by
- metribolone
- LAMA4
role in cell
- cell death
- morphogenesis
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- motile cilia
- ciliary tip
- non-motile cilium
- cilia
- connecting cilia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wdr19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- macromolecular complex assembly
- embryonic camera-type eye development
- cell morphogenesis
- myotome development
- embryonic cranial skeleton morphogenesis
- receptor clustering
- smoothened signaling pathway involved in dorsal/ventral neural tube patterning
- embryonic limb morphogenesis
- gonad development
- in utero embryonic development
- ear morphogenesis
- digestive system development
- neurological system process
- intraflagellar retrograde transport
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- motile cilium
- cytoskeleton
- cytoplasm
- cilium
- intraflagellar transport particle A
- plasma membrane
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- protein binding