Dpm3 Gene Summary [Rat]
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Dpm3 |
| Official Name | dolichyl-phosphate mannosyltransferase subunit 3, regulatory [Source:RGD Symbol;Acc:1561807] |
| Ensembl ID | ENSRNOG00000029077 |
| Bio databases IDs | |
| Aliases | dolichyl-phosphate mannosyltransferase subunit 3, regulatory |
| Synonyms | 1110001H19Rik, AV117483, CDG1O, dolichyl-phosphate mannosyltransferase polypeptide 3, dolichyl-phosphate mannosyltransferase subunit 3, regulatory, MDDGB15, MDDGC15, RGD1561807 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dpm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dolichyl-phosphate beta-D-mannosyltransferase
- Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
- protein binding activity, bridging
- enzyme
- protein binding
- enzyme activator activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type 1O
- congenital muscular dystrophy-dystroglycanopathy with impaired intellectual development type B15
regulates
- dolichol monophosphate mannose
- DPM1
- dolichol 20
role in cell
- apoptosis
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum fraction
- perinuclear region
- filamentous network
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dpm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan
- GPI anchor biosynthetic process
- carbohydrate metabolic process
- regulation of protein stability
- dolichol metabolic process
- protein mannosylation
- protein O-linked mannosylation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- dolichol-phosphate-mannose synthase complex
- endoplasmic reticulum
- mannosyltransferase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme activator activity