Ppp2r1a Gene Summary [Rat]
Predicted to enable several functions, including protein antigen binding activity; protein heterodimerization activity; and protein phosphatase regulator activity. Predicted to be involved in several processes, including T cell homeostasis; meiotic sister chromatid cohesion, centromeric; and negative regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including nuclear division; peptidyl-serine dephosphorylation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in several cellular components, including chromosome, centromeric region; lateral plasma membrane; and neuronal cell body. Predicted to be part of FAR/SIN/STRIPAK complex and protein phosphatase type 2A complex. Predicted to be active in cytosol; glutamatergic synapse; and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp2r1a |
| Official Name | protein phosphatase 2 scaffold subunit A alpha [Source:RGD Symbol;Acc:620907] |
| Ensembl ID | ENSRNOG00000011282 |
| Bio databases IDs | |
| Aliases | protein phosphatase 2 scaffold subunit A alpha |
| Synonyms | 6330556D22Rik, HJS2, MRD36, PP2A, PP2A-A, PP2A/A, PP2A AALPHA, PP2A-A α, Pp2a-pr65, PR65, PR65A, protein phosphatase 2, regulatory subunit A, alpha, protein phosphatase 2, regulatory subunit A, α, protein phosphatase 2 scaffold subunit A alpha, protein phosphatase 2 scaffold subunit A α, α 4 regulatory subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppp2r1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HEAT repeat
- protein serine/threonine phosphatase
- phosphoprotein phosphatase
- catalytic subunit-binding domain
- phosphatase
- protein phosphatase regulator
- antigen binding
- protein binding
- loop domain
- HEAT repeats
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Ppp2r1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Autophagy
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Ceramide Signaling
- Cyclins and Cell Cycle Regulation
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Mitotic Roles of Polo-Like Kinase
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of eIF4 and p70S6K Signaling
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Role of Tissue Factor in Cancer
- Telomerase Signaling
- Tight Junction Signaling
- WNT/β-catenin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- transitional cell bladder cancer
- urothelial bladder carcinoma
- breast adenocarcinoma
- autosomal dominant mental retardation type 36
- lung squamous cell carcinoma
- squamous cell lung cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- non-small cell lung cancer
role in cell
- activation in
- expression in
- cell death
- production in
- cell viability
- damage in
- phosphorylation in
- colony formation
- apoptosis
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear membrane fraction
- membrane fraction
- glutaminergic synapse
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- lateral plasma membrane
- neurites
- synaptosomes
- synapse
- membrane rafts
- cellular protrusions
- centromeres
- chromatin
- perikaryon
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppp2r1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of hippo signaling cascade
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
- macromolecular complex assembly
- female meiosis
- protein dephosphorylation
- chromosome segregation
- regulation of growth
- T cell homeostasis
- regulation of cell differentiation
- meiotic spindle elongation
- mitotic sister chromatid separation
- intracellular signal transduction
- meiotic sister chromatid cohesion, centromeric
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- lateral plasma membrane
- neuronal cell body
- protein phosphatase type 2A complex
- chromosome, centromeric region
- neuron projection
- nucleus
- dendrite
- extracellular vesicular exosome
- cytoplasm
- membrane
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- protein heterodimerization activity
- protein phosphatase regulator activity