Sec22b Gene Summary [Rat]
Enables syntaxin binding activity. Predicted to be involved in Golgi vesicle transport and regulation of catabolic process. Predicted to act upstream of or within vesicle-mediated transport. Located in COPI-coated vesicle. Part of SNARE complex. Is active in synaptic vesicle. Orthologous to human SEC22B (SEC22 homolog B, vesicle trafficking protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sec22b |
| Official Name | SEC22 homolog B, vesicle trafficking protein [Source:RGD Symbol;Acc:1309988] |
| Ensembl ID | ENSRNOG00000018673 |
| Bio databases IDs | |
| Aliases | SEC22 homolog B, vesicle trafficking protein |
| Synonyms | 4930564D15RIK, ERS-24, SEC22 homolog B, vesicle trafficking protein, SEC22L1, Sec22 vesicle trafficking protein like 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sec22b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulated-SNARE-like domain
- cytoplasmic domain
- transmembrane domain
- protein binding
- SNARE motif
- Longin-like domains
- Synaptobrevin
- syntaxin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- aortic valve calcification
- uterine leiomyoma
- leiomyomatosis
role in cell
- expression in
- growth
- formation
- formation in
- degradation in
- fusion
- cross-presentation by
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum fraction
- membrane fraction
- Golgi-intermediate compartment membrane fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- perinuclear Golgi regions
- cellular membrane
- Nucleus
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- membrane compartment
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum membrane
- Golgi membrane
- inner nuclear membrane
- synaptic vesicles
- transport vesicles
- cytoplasmic vesicles
- microsomal membrane
- Golgi cisternae
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sec22b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- retrograde vesicle-mediated transport, Golgi to ER
- protein transport
- positive regulation of protein catabolic process
- vesicle fusion with Golgi apparatus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- melanosome
- ER to Golgi transport vesicle membrane
- SNARE complex
- phagocytic vesicle membrane
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment
- transport vesicle
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNAP receptor activity