Nrbp2 Gene Summary [Rat]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; negative regulation of macroautophagy; and negative regulation of neuron apoptotic process. Predicted to be active in cytoplasm and endomembrane system. Orthologous to human NRBP2 (nuclear receptor binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrbp2 |
| Official Name | nuclear receptor binding protein 2 [Source:RGD Symbol;Acc:1591749] |
| Ensembl ID | ENSRNOG00000029535 |
| Bio databases IDs | |
| Aliases | nuclear receptor binding protein 2 |
| Synonyms | LOC100653301, LOC684607, nuclear receptor binding protein 2, pp9320, TRG16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nrbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Serine/Threonine protein kinases, catalytic domain
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
role in cell
- expression in
- apoptosis
- phosphorylation in
- perifosine sensitivity
- cisplatin sensitivity
- formation by
- downregulation in
- macroautophagy in
- upregulation in
- sorafenib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nrbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- negative regulation of macroautophagy
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity