Psmb4 Gene Summary [Rat]
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Psmb4 |
| Official Name | proteasome 20S subunit beta 4 [Source:RGD Symbol;Acc:61877] |
| Ensembl ID | ENSRNOG00000020979 |
| Bio databases IDs | |
| Aliases | proteasome 20S subunit beta 4 |
| Synonyms | HN3, HsN3, Lmp3, Macropain beta chain, Macropain β chain, PRAAS3, PROS-26, Pros-27, proteasome 20S subunit beta 4, proteasome 20S subunit β 4, PROTEASOME beta CHAIN, Proteasome chain 3, proteasome (prosome, macropain) subunit, beta type 4, proteasome (prosome, macropain) subunit, β type 4, PROTEASOME β CHAIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Psmb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- peptidase
- protein binding
- Proteasome subunit
- lipopolysaccharide binding
Pathways
Biological processes and signaling networks where the Psmb4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- major depression
- breast cancer
- organismal death
- proteasome-associated autoinflammatory syndrome 3
- tuberculoid leprosy
- lung cancer
- proteasome associated autoinflammatory syndrome 1
- digenic proteasome associated autoinflammatory syndrome type 3
- digenic proteasome-associated autoinflammation syndrome 1/3
role in cell
- cell survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- basal bodies
- Mitochondria
- cytosol
- nucleoplasm
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Psmb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response to antigenic stimulus
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cilium basal body
- proteasome core complex
- mitochondrion
- cytosol
- proteasome complex
- proteasome core complex, beta-subunit complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipopolysaccharide binding