Golgb1 Gene Summary [Rat]
Involved in chondrocyte proliferation. Predicted to be located in Golgi apparatus. Predicted to be active in cis-Golgi network and endoplasmic reticulum-Golgi intermediate compartment. Used to study osteochondrodysplasia. Orthologous to human GOLGB1 (golgin B1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Golgb1 |
| Official Name | golgin B1 [Source:RGD Symbol;Acc:708429] |
| Ensembl ID | ENSRNOG00000030314 |
| Bio databases IDs | |
| Aliases | golgin B1 |
| Synonyms | 4930428L02RIK, 6330407A06RIK, C130074L01Rik, F730017E11RIK, GCP, GCP372, Giantin, Gm6840, GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY B member 1, GOLGIB1, golgin B1, GOLIM1, LOC192243, mKIAA4151 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Golgb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Hyaluronan mediated motility receptor N-terminal
- Synaptonemal complex protein 1 (SCP-1)
- rad50
- Myosin tail
- helix-rich Mycoplasma protein
- coiled-coil domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myeloid/lymphoid neoplasm with eosinophilia
- hematological neoplasia
- metabolic syndrome X
role in cell
- proliferation
- growth
- organization
- docking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- detergent-insoluble fractions
- membrane fraction
- juxtanuclear Golgi region
- perinuclear region
- cellular membrane
- vesicles
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- cytosol
- cisternae
- Golgi membrane
- Golgi stacks
- Golgi cisternae rim
- cis Golgi networks
- spine apparatus
- peri-Golgi vesicles
- Golgi cisternae
- perikaryon
- axons
- dendrites
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Golgb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Golgi organization
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- cis-Golgi network
- membrane
- cytosol
- Golgi apparatus
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment
- Golgi stack
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- sequence-specific DNA binding