Rab7a Gene Summary [Rat]
Enables GDP binding activity; GTP binding activity; and small GTPase binding activity. Involved in bone resorption and synaptic vesicle recycling via endosome. Located in alveolar lamellar body and late endosome. Is active in presynaptic endosome and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Orthologous to human RAB7A (RAB7A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab7a |
| Official Name | RAB7A, member RAS oncogene family [Source:RGD Symbol;Acc:61908] |
| Ensembl ID | ENSRNOG00000012247 |
| Bio databases IDs | |
| Aliases | RAB7A, member RAS oncogene family |
| Synonyms | CMT2B, PRO2706, RAB7, RAB7A, member RAS oncogene family, RAB7, member RAS oncogene family, Ras Related Protein p23 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab7a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- small monomeric GTPase
- 50S ribosome-binding GTPase
- alpha helix
- enzyme binding
- GTPase
- enzyme
- protein binding
- prenylation site
- Ras subfamily of RAS small GTPases
- GTP binding
- CXC prenylation site
- binding protein
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Elongation factor Tu GTP binding domain
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rab7a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- organismal death
- Charcot-Marie-Tooth disease type 2
- papillary renal cell carcinoma
- papillary renal cell neoplasia
- renal cell cancer
- Charcot-Marie-Tooth disease axonal, type 2B
- urothelial bladder carcinoma
- transitional cell bladder cancer
- hepatocellular carcinoma
role in cell
- quantity
- formation
- formation in
- expression in
- migration
- Gap 0-Gap 1 phase
- phosphorylation in
- invasion by
- survival
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- synaptic vesicle membrane
- glutaminergic synapse
- intracellular membrane-bounded organelle
- exocytic vesicle
- perinuclear region
- cellular membrane
- vacuole
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- Mitochondria
- secretory granule membrane
- lipid droplets
- cytosol
- Golgi membrane
- lysosome membrane
- endosomal compartment
- endosomal membrane
- alveolar epithelial lamellar bodies
- late endosomes
- perinuclear vesicles
- cytoplasmic vesicles
- endocytotic vesicle
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- axons
- exosomes
- phagosomes
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab7a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein to membrane docking
- intracellular transport
- protein transport
- epidermal growth factor catabolic process
- positive regulation of protein catabolic process
- phagosome-lysosome fusion
- positive regulation of viral reproduction
- phagosome maturation
- endosome to lysosome transport
- phagosome acidification
- retrograde transport, endosome to Golgi
- endocytosis
- protein targeting to lysosome
- autophagic vacuole assembly
- response to bacterium
- release of virus from host
- bone resorption
- establishment of vesicle localization
- lipid catabolic process
- early endosome to late endosome transport
Cellular Component
Where in the cell the gene product is active
- melanosome membrane
- pre-autophagosomal structure membrane
- phagocytic vesicle
- late endosome
- Golgi apparatus
- lysosomal membrane
- autophagic vacuole membrane
- plasma membrane
- lysosome
- lipid particle
- late endosome membrane
- secretory granule membrane
- extracellular vesicular exosome
- mitochondrial membrane
- mitochondrion
- retromer complex
- phagocytic vesicle membrane
- cytosol
- endosome membrane
- synaptic vesicle membrane
- alveolar lamellar body
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding
- small GTPase binding