Calhm1 Gene Summary [Rat]
Predicted to enable calcium-activated cation channel activity; identical protein binding activity; and voltage-gated calcium channel activity. Predicted to be involved in several processes, including ATP export; protein complex oligomerization; and sensory perception of taste. Predicted to be located in basolateral plasma membrane and plasma membrane raft. Predicted to be active in plasma membrane. Orthologous to human CALHM1 (calcium homeostasis modulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Calhm1 |
| Official Name | calcium homeostasis modulator 1 [Source:RGD Symbol;Acc:1564891] |
| Ensembl ID | ENSRNOG00000030682 |
| Bio databases IDs | |
| Aliases | calcium homeostasis modulator 1 |
| Synonyms | calcium homeostasis modulator 1, FAM26C, RGD1564891 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Calhm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- calcium activated cation channel
- Calcium homeostasis modulator
- channel/pore class transporter
- protein binding
- identical protein binding
- voltage-gated ion channel
- ion channel
Pathways
Biological processes and signaling networks where the Calhm1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- basolateral membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Calhm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cation transport
- sensory perception of umami taste
- sensory perception of sweet taste
- protein homooligomerization
- sensory perception of bitter taste
- calcium ion transmembrane transport
- regulation of ion transmembrane transport
- protein heterooligomerization
- ATP transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium activated cation channel activity
- identical protein binding
- protein binding
- cation channel activity
- voltage-gated ion channel activity
- voltage-gated calcium channel activity