Csnk1d Gene Summary [Rat]
This gene encodes a member of the casein kinase I (CKI) family of serine/threonine protein kinases. A highly similar human protein regulates an array of cellular processes by influencing the Wnt and hedgehog signaling pathways. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | Csnk1d |
| Official Name | casein kinase 1, delta [Source:RGD Symbol;Acc:71031] |
| Ensembl ID | ENSRNOG00000036676 |
| Bio databases IDs | |
| Aliases | casein kinase 1, delta |
| Synonyms | 1200006A05Rik, ASPS, casein kinase 1 delta, casein kinase 1, delta, casein kinase 1 δ, casein kinase 1, δ, Ck1 delta, Ck1 δ, CKId, CKI-delta, CKI-δ, D930010H05RIK, FASPS2, HCKID |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Csnk1d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- centrosomal localization signal
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Tau-protein kinase
- Protein Kinases, catalytic domain
- SQIP motif
- alcohol group acceptor phosphotransferase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Csnk1d gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Circadian Rhythm Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Gap Junction Signaling
- HIPPO signaling
- Hypoxia Signaling in the Cardiovascular System
- p53 Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Regulation of the Immune Response
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- familial advanced sleep phase syndrome type 2
role in cell
- binding in
- proliferation
- expression in
- phosphorylation in
- accumulation in
- growth
- binding
- nucleation
- outgrowth
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- spindle apparatus
- cilia
- perinuclear region
- cellular membrane
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- basal bodies
- centrosome
- Golgi Apparatus
- cytosol
- nucleoplasm
- spindle fibers
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Csnk1d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- protein localization in Golgi apparatus
- Golgi organization
- positive regulation of non-canonical Wnt receptor signaling pathway
- microtubule nucleation
- positive regulation of canonical Wnt receptor signaling pathway
- protein phosphorylation
- regulation of circadian rhythm
- endocytosis
- COPII vesicle coating
- spindle assembly
- circadian regulation of gene expression
- positive regulation of protein phosphorylation
- Wnt receptor signaling pathway
- peptidyl-serine phosphorylation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein localization to centrosome
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- Golgi apparatus
- plasma membrane
- nucleoplasm
- spindle microtubule
- nucleus
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- spindle
- cytosol
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- tau-protein kinase activity
- ATP binding
- protein binding
- cadherin binding
- protein kinase activity
- protein serine/threonine kinase activity