Mt-co3 Gene Summary [Rat]
Predicted to enable electron transfer activity and oxidoreduction-driven active transmembrane transporter activity. Involved in respiratory chain complex IV assembly. Part of respiratory chain complex IV. Implicated in MELAS syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | Mt-co3 |
| Official Name | mitochondrially encoded cytochrome c oxidase III [Source:RGD Symbol;Acc:621873] |
| Ensembl ID | ENSRNOG00000030700 |
| Bio databases IDs | |
| Aliases | mitochondrially encoded cytochrome c oxidase III |
| Synonyms | COIII, COX3, COX III, CY3, Cytochrome C Oxidase Subunit 3, cytochrome c oxidase subunit III, CytOX III, Mitochondrial cytochrome oxidase III, Similar to bcdo |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mt-Co3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- Heme_Cu_Oxidase_III_like
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Mt-Co3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- Alzheimer disease
- Leber optic atrophy
- precursor B-cell acute lymphoblastic leukemia
- nuclear type 1 mitochondrial complex iv deficiency
- androgenic alopecia
- cytochrome c oxidase deficiency
- mitochondrial disorder
- Huntington disease
- medulloblastoma
regulates
- adenosine triphosphate
- cytochrome-c oxidase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mt-Co3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial electron transport, cytochrome c to oxygen
- cellular respiration
- respiratory chain complex IV assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- respiratory chain complex IV
- mitochondrion
- mitochondrial respiratory chain complex IV
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- cytochrome-c oxidase activity
- protein binding