Gc Gene Summary [Rat]
Enables vitamin D binding activity. Involved in several processes, including female pregnancy; lactation; and response to estradiol. Located in axon; extracellular space; and perinuclear region of cytoplasm. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gc |
| Official Name | GC, vitamin D binding protein [Source:RGD Symbol;Acc:2667] |
| Ensembl ID | ENSRNOG00000003119 |
| Bio databases IDs | |
| Aliases | GC, vitamin D binding protein |
| Synonyms | DBP, DBP02, DBP/GC, DBP-maf, Gc-MAF, GC vitamin D binding protein, GC, vitamin D binding protein, GRD3, Group-specific Component, HEL-S-51, VDB, VDBG, VDBP, Vitamin D binding, vitamin D binding protein, Vitamin d binding protein prepeptide |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ALBUMIN
- vitamin D binding
- actin binding
- protein binding
- Vitamin D binding protein, domain III
- transporter
Pathways
Biological processes and signaling networks where the Gc gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- COVID-19
- liver cancer
- epithelial cancer
- measles
- diabetic nephropathy
- Marfan syndrome
- insulin-dependent diabetes mellitus
- chronic obstructive pulmonary disease
- streptozotocin-induced diabetic nephropathy
role in cell
- expression in
- function
- activation
- cell movement
- recruitment
- aggregation
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perinuclear region
- Plasma Membrane
- cytosol
- lysosomal compartment
- axons
- exosomes
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vitamin transmembrane transport
- vitamin transport
- transport
- vitamin D metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- blood microparticle
- cytosol
- lysosomal lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- actin binding
- vitamin D binding