Slc6a5 Gene Summary [Rat]
Enables glycine:sodium symporter activity. Involved in glycine transport. Located in dense core granule and endosome. Is active in glycinergic synapse and presynaptic membrane. Human ortholog(s) of this gene implicated in hyperekplexia 3. Orthologous to human SLC6A5 (solute carrier family 6 member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc6a5 |
| Official Name | solute carrier family 6 member 5 [Source:RGD Symbol;Acc:621824] |
| Ensembl ID | ENSRNOG00000031662 |
| Bio databases IDs | |
| Aliases | solute carrier family 6 member 5 |
| Synonyms | GLYT-2, HKPX3, NET1, prestin, solute carrier family 6 member 5, solute carrier family 6 (neurotransmitter transporter, glycine), member 5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc6a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycine:sodium symporter
- Sodium:neurotransmitter symporter family
- glycine transporter
- Solute carrier families 5 and 6-like; solute binding domain
- PDZ binding motif
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- autosomal recessive hyperekplexia type 3
- autosomal dominant hyperekplexia type 3
- postoperative pain
- tremor
- hereditary disorder
- acute pain
- weight gain
- hypertonia
- hyperekplexia
role in cell
- transmission
- binding in
- endocytosis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- membrane surface
- cellular membrane
- endosomes
- vesicles
- apical membrane
- presynaptic membrane
- synaptic vesicles
- nerve ending
- synapse
- dense-core vesicles
- secretory granules
- membrane processes
- perikaryon
- dendrites
- axon terminals
- presynaptic terminals
- postsynaptic terminals
- inhibitory synapse
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc6a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neurotransmitter transport
- synaptic transmission, glycinergic
- synaptic transmission
- sodium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- endosome
- membrane
- dense core granule
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- glycine:sodium symporter activity
- metal ion binding