Stx1a Gene Summary [Rat]
Enables several functions, including ATP-dependent protein binding activity; calcium-dependent protein binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; positive regulation of secretion by cell; and synaptic vesicle docking. Located in actomyosin; plasma membrane; and secretory granule. Part of several cellular components, including synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; synaptic membrane; and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease and Hirschsprung's disease. Orthologous to human STX1A (syntaxin 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stx1a |
| Official Name | syntaxin 1A [Source:RGD Symbol;Acc:69430] |
| Ensembl ID | ENSRNOG00000029165 |
| Bio databases IDs | |
| Aliases | syntaxin 1A |
| Synonyms | HPC-1, LOC100360064, P35-1, STX1, SYN1A, Syntaxin 1A, syntaxin 1A (brain) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stx1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- CaMKII binding domain
- membrane-association domain
- protein binding activity, bridging
- coiled-coil domain
- identical protein binding
- myosin binding
- cytoplasmic domain
- ATP-dependent protein binding
- ion channel binding
- Syntaxin
- calcium-dependent protein binding
- calcium channel inhibitor
- alpha helix
- linker domain
- protein binding
- chloride channel inhibitor activity
- binding protein
- kinase binding
- SynN
- SNARE domain
- membrane attachment signal
- Helical region found in SNAREs
- transmembrane domain
- histone H3 binding domain
- cytosolic tail domain
- SNARE motif
- transporter
Pathways
Biological processes and signaling networks where the Stx1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- major depression
- hyperactive behavior
- malaria
- growth failure
- pituitary gland adenoma
- head and neck neuroendocrine neoplasia
role in cell
- quantity
- cell viability
- apoptosis
- recruitment
- recruitment in
- number
- priming
- endocytosis
- fusion
- docking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- intracellular membrane fractions
- membrane fraction
- synaptic vesicle membrane
- glutaminergic synapse
- Extracellular Space
- intracellular membranes
- membrane surface
- cellular membrane
- actin cytoskeleton
- Plasma Membrane
- cytosol
- cytoplasmic face of plasma membrane
- presynaptic membrane
- synaptic membrane
- nuclear envelope
- acrosome
- synaptic vesicles
- neurites
- synaptosomes
- synapse
- secretory granules
- membrane rafts
- axons
- postsynaptic density
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stx1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin secretion
- protein sumoylation
- intracellular protein transport
- exocytosis
- positive regulation of calcium ion-dependent exocytosis
- regulation of insulin secretion
- positive regulation of catecholamine secretion
- regulation of synaptic vesicle priming
- synaptic vesicle endocytosis
- vesicle docking
- positive regulation of neurotransmitter secretion
- synaptic vesicle fusion to presynaptic membrane
- calcium ion-dependent exocytosis
- positive regulation of norepinephrine secretion
- positive regulation of excitatory postsynaptic membrane potential
- synaptic vesicle exocytosis
- secretion by cell
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- synaptic vesicle
- presynaptic active zone membrane
- extracellular region
- neuron projection
- plasma membrane
- nuclear membrane
- synaptobrevin 2-SNAP-25-syntaxin-1a complex
- SNARE complex
- cytosol
- endomembrane system
- synaptic vesicle membrane
- axon
Molecular Function
What the gene product does at the molecular level
- chloride channel inhibitor activity
- identical protein binding
- protein binding
- SNAP receptor activity
- SNARE binding
- kinase binding
- calcium channel inhibitor activity