Gpr174 Gene Summary [Rat]
Predicted to enable bioactive lipid receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and negative regulation of interleukin-2 production. Predicted to act upstream of or within T cell homeostasis. Predicted to be located in centriolar satellite and intracellular membrane-bounded organelle. Predicted to be active in plasma membrane. Orthologous to human GPR174 (G protein-coupled receptor 174). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr174 |
| Official Name | G protein-coupled receptor 174 [Source:RGD Symbol;Acc:1564689] |
| Ensembl ID | ENSRNOG00000032970 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 174 |
| Synonyms | FKSG79, Gm376, GPCR17, G protein-coupled receptor 174, LOC107985690, LPS3, LYPSR3, RGD1564689 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gpr174 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- bioactive lipid receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpr174 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- centrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gpr174 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-2 production
- positive regulation of Rho protein signal transduction
- phospholipase C-activating G-protein coupled receptor signaling pathway
- T cell homeostasis
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- centriolar satellite
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- bioactive lipid receptor activity