RT1-Db1 Gene Summary [Rat]
Predicted to enable several functions, including MHC class II receptor activity; peptide antigen binding activity; and signaling receptor binding activity. Involved in response to dexamethasone. Predicted to be located in external side of plasma membrane and immunological synapse. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and sarcoidosis (multiple). Orthologous to several human genes including HLA-DRB1 (major histocompatibility complex, class II, DR beta 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | RT1-Db1 |
| Official Name | RT1 class II, locus Db1 [Source:RGD Symbol;Acc:1593282] |
| Ensembl ID | ENSRNOG00000033215 |
| Bio databases IDs | |
| Aliases | RT1 class II, locus Db1 |
| Synonyms | Db1, Eb, H-2Eb, histocompatibility 2, class II antigen E beta, histocompatibility 2, class II antigen E β, Hla-dqb2, Ia-4, Mhc class2 beta, Mhc class2 β, RT1 class II, locus Db1, RT1-Db, RT1-Db1, RT1-Db1n, Rt1.d beta chain similar to class ii mhc rt1.d(n) beta chain precursor, Rt1.d β chain similar to class ii mhc rt1.d(n) β chain precursor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rt1-Db1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- MHC class II receptor
- immunoglobulin domain
- T-cell receptor binding
- protein binding
- polysaccharide binding
- transmembrane receptor
- peptide antigen binding
- Class II histocompatibility antigen, beta domain
- CD4 receptor binding
Pathways
Biological processes and signaling networks where the Rt1-Db1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- immunological synapses
- plasma membrane extracellular face
- lysosome membrane
- endosomal membrane