Npc1 Gene Summary [Rat]
Predicted to enable cholesterol binding activity and cholesterol transfer activity. Involved in negative regulation of epithelial cell apoptotic process and response to cadmium ion. Predicted to be located in several cellular components, including bounding membrane of organelle; membrane raft; and perinuclear region of cytoplasm. Predicted to be active in lysosome and plasma membrane. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Orthologous to human NPC1 (NPC intracellular cholesterol transporter 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npc1 |
| Official Name | NPC intracellular cholesterol transporter 1 [Source:RGD Symbol;Acc:628693] |
| Ensembl ID | ENSRNOG00000012016 |
| Bio databases IDs | |
| Aliases | NPC intracellular cholesterol transporter 1 |
| Synonyms | A430089E03Rik, Cdig2, D18Ertd139e, D18Ertd723e, lcsd, nmf164, NPC, NPC intracellular cholesterol transporter 1, POGZ, SLC65A1, SLC66A1, spm |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Npc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cholesterol binding
- signaling receptor activity
- leucine zipper domain
- protein binding
- lipid transporter
- Patched family
- cytoplasmic domain
- The Eukaryotic (Putative) Sterol Transporter (EST) Family
- lumenal domain
- Niemann-Pick C1 N terminus
- transmembrane domain
- Sterol-sensing domain of SREBP cleavage-activation
- Niemann-Pick C type protein family
- sterol sensing domain
- transmembrane receptor
- cysteine rich domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- neoplasia
- non-insulin-dependent diabetes mellitus
- fibrosis
- heart failure
- cardiovascular disorder
- Niemann-Pick disease type C1
- coronary artery disease
- Niemann-Pick disease type C
- Niemann-Pick disease, type D
role in cell
- growth
- cell death
- expression in
- accumulation in
- apoptosis
- cellular infiltration by
- necrosis
- proliferation
- phosphorylation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- endoplasmic reticulum mitochondria contact site
- Extracellular Space
- cell periphery
- perinuclear region
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- granules
- trans Golgi network
- lysosome membrane
- endosomal membrane
- nuclear envelope
- late endosomes
- cytoplasmic vesicles
- endocytotic vesicle
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Npc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- protein glycosylation
- cholesterol metabolic process
- neurogenesis
- response to xenobiotic stimulus
- cholesterol homeostasis
- bile acid metabolic process
- establishment of protein localization in membrane
- adult walking behavior
- cholesterol storage
- autophagy
- liver development
- intracellular cholesterol transport
- intracellular lipid transport
- cholesterol transport
- membrane raft organization
- macroautophagy
- lysosomal transport
- response to cadmium ion
- endocytosis
- cellular response to steroid hormone stimulus
- cyclodextrin metabolic process
- gene expression
- negative regulation of macroautophagy
- intestinal cholesterol absorption
- cholesterol efflux
- programmed cell death
- cellular response to low-density lipoprotein particle stimulus
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- endoplasmic reticulum
- extracellular region
- plasma membrane
- lysosomal membrane
- lysosome
- nuclear envelope
- late endosome membrane
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- membrane raft
- membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- cholesterol binding
- lipid transporter activity
- signaling receptor activity
- viral receptor activity