Fam107a Gene Summary [Rat]
Predicted to enable actin binding activity. Predicted to be involved in several processes, including actin filament organization; regulation of cell junction assembly; and regulation of cytoskeleton organization. Located in neuron projection. Orthologous to human FAM107A (family with sequence similarity 107 member A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fam107a |
| Official Name | family with sequence similarity 107, member A [Source:RGD Symbol;Acc:1306327] |
| Ensembl ID | ENSRNOG00000033261 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 107, member A |
| Synonyms | DRR, DRR1, family with sequence similarity 107 member A, family with sequence similarity 107, member A, LOC100364831, RGD1306327, TU3A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fam107a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Protein of unknown function (DUF1151)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- small cell lung cancer
- colorectal cancer
- Huntington disease
- non-small cell lung cancer
- glioma formation
- doxorubicin induced cardiotoxicity
- idiopathic pulmonary fibrosis
- glioma
regulates
- AKT
- FAM107A
- F Actin
role in cell
- migration
- phosphorylation in
- growth
- assembly
- invasiveness
- density
- outgrowth
- invasion by
- disassembly
- outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- cytoskeleton
- Cytoplasm
- focal adhesions
- actin cytoskeleton
- membrane ruffles
- nuclear speckles
- neurites
- synapse
- actin stress fibers
- presynaptic terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fam107a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of long-term synaptic potentiation
- regulation of microtubule cytoskeleton organization
- actin filament polymerization
- negative regulation of focal adhesion assembly
- regulation of protein stability
- regulation of actin cytoskeleton organization
- cellular response to nutrient levels
- cognition
- regulation of cell growth
- cellular response to glucocorticoid stimulus
- positive regulation of protein ubiquitination
- negative regulation of G1/S transition of mitotic cell cycle
- actin filament bundle assembly
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- focal adhesion
- cytoplasm
- nuclear speck
- stress fiber
- actin cytoskeleton
- ruffle membrane
- synapse
- neuron projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding