Set Gene Summary [Rat]

Enables chromatin binding activity. Involved in endothelial cell differentiation and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; lipid droplet; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
Set
Official Name
SET nuclear proto-oncogene [Source:RGD Symbol;Acc:1307467]
Ensembl ID
ENSRNOG00000034241
Bio databases IDs NCBI: 307947 Ensembl: ENSRNOG00000034241
Aliases SET nuclear proto-oncogene
Synonyms Ab1-115, Set, SET like protein, SETP18
Species
Rat, Rattus norvegicus
OrthologiesHuman

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Set often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Nucleosome assembly protein (NAP)
  • PTZ00007
  • chromatin binding
  • protein binding

Pathways

Biological processes and signaling networks where the Set gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
  • DNA promoter
  • DNA endogenous promoter
  • CYP17A1
  • RNA polymerase II
  • PPP2CA
disease
  • autosomal dominant mental retardation type 58
role in cell
  • differentiation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • perinuclear region
  • cellular membrane
  • Nucleus
  • Endoplasmic Reticulum
  • lipid droplets
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Set gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • endothelial cell differentiation
  • positive regulation of transcription from RNA polymerase II promoter
  • nucleosome assembly

Cellular Component

Where in the cell the gene product is active
  • lipid particle
  • nucleus
  • cytoplasm
  • chromatin
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • histone binding
  • chromatin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.