Tbcd Gene Summary [Rat]
Predicted to enable GTPase activator activity and beta-tubulin binding activity. Predicted to be involved in several processes, including cell-cell junction assembly; post-chaperonin tubulin folding pathway; and tubulin complex assembly. Predicted to be located in centrosome. Predicted to be active in lateral plasma membrane. Human ortholog(s) of this gene implicated in early onset progressive encephalopathy with brain atrophy and thin corpus callosum. Orthologous to human TBCD (tubulin folding cofactor D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbcd |
| Official Name | tubulin folding cofactor D [Source:RGD Symbol;Acc:2320148] |
| Ensembl ID | ENSRNOG00000036658 |
| Bio databases IDs | |
| Aliases | tubulin folding cofactor D |
| Synonyms | 2310057L06Rik, A030005L14Rik, LOC363309, mKIAA0988, PEBAT, SSD-1, tfcD, tubulin folding cofactor D, tubulin-specific chaperone d |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tbcd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- Tubulin folding cofactor D C terminal
- GTPase activator
- protein binding
- chaperone binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- early-onset progressive encephalopathy with brain atrophy and thin corpus callosum
- seborrheic keratosis
- Duchenne muscular dystrophy
- coronary artery disease
- hereditary disorder
- non-insulin-dependent diabetes mellitus
- systemic lupus erythematosus
- juvenile dermatomyositis
- spontaneous preterm birth
- systemic juvenile idiopathic arthritis
regulates
- tubulin
role in cell
- disruption
- polymerization
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- microtubules
- lateral plasma membrane
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tbcd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tubulin complex assembly
- negative regulation of cell-substrate adhesion
- tight junction assembly
- cell morphogenesis involved in neuron differentiation
- post-chaperonin tubulin folding pathway
- microtubule cytoskeleton organization
- adherens junction assembly
- protein folding
- mitotic cell cycle
- negative regulation of microtubule polymerization
Cellular Component
Where in the cell the gene product is active
- adherens junction
- lateral plasma membrane
- tight junction
- centrosome
- cytoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-tubulin binding
- GTPase activator activity
- chaperone binding