TBCD Gene Summary [Human]
Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TBCD |
| Official Name | tubulin folding cofactor D [Source:HGNC Symbol;Acc:HGNC:11581] |
| Ensembl ID | ENSG00000141556 |
| Bio databases IDs | |
| Aliases | tubulin folding cofactor D |
| Synonyms | 2310057L06Rik, A030005L14Rik, LOC363309, mKIAA0988, PEBAT, SSD-1, tfcD, tubulin folding cofactor D, tubulin-specific chaperone d |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TBCD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- Tubulin folding cofactor D C terminal
- GTPase activator
- protein binding
- chaperone binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- tubulin
disease
- early-onset progressive encephalopathy with brain atrophy and thin corpus callosum
- seborrheic keratosis
- Duchenne muscular dystrophy
- coronary artery disease
- hereditary disorder
- non-insulin-dependent diabetes mellitus
- systemic lupus erythematosus
- juvenile dermatomyositis
- spontaneous preterm birth
- systemic juvenile idiopathic arthritis
role in cell
- disruption
- polymerization
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- microtubules
- lateral plasma membrane
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TBCD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tubulin complex assembly
- negative regulation of cell-substrate adhesion
- tight junction assembly
- cell morphogenesis involved in neuron differentiation
- post-chaperonin tubulin folding pathway
- microtubule cytoskeleton organization
- adherens junction assembly
- protein folding
- mitotic cell cycle
- negative regulation of microtubule polymerization
Cellular Component
Where in the cell the gene product is active
- adherens junction
- lateral plasma membrane
- tight junction
- centrosome
- cytoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-tubulin binding
- GTPase activator activity
- chaperone binding