Mrm3 Gene Summary [Rat]

Predicted to enable identical protein binding activity and rRNA (guanosine-2'-O-)-methyltransferase activity. Predicted to be involved in rRNA processing. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human MRM3 (mitochondrial rRNA methyltransferase 3). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Mrm3
Official Name
mitochondrial rRNA methyltransferase 3 [Source:RGD Symbol;Acc:1309077]
Ensembl ID
ENSRNOG00000037238
Bio databases IDs NCBI: 360569 Ensembl: ENSRNOG00000037238
Aliases mitochondrial rRNA methyltransferase 3
Synonyms 4833420N02RIK, FLJ10581, HC90, LOC100360580, mitochondrial rRNA methyltransferase 3, RGD1309077, RMTL1, RNMTL1
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mrm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • O-methyltransferase
  • RNA 2'-O ribose methyltransferase substrate binding
  • rRNA methylase, putative, group 3
  • SPOUT superfamily of SAM-dependent RNA methyltransferases
  • RNA methyltransferase
  • enzyme
  • protein binding
  • identical protein binding
  • rRNA (guanine) methyltransferase

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • non-small cell lung cancer
regulated by
regulates
  • NFkB (complex)
  • Mitochondrial Ribosome 39S Subunit
role in cell
  • activation in
  • translation in
  • assembly in
  • mitochondrial respiration in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Mitochondria
  • mitochondrial matrix

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Mrm3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • rRNA 2'-O-methylation

Cellular Component

Where in the cell the gene product is active
  • mitochondrial matrix
  • mitochondrion

Molecular Function

What the gene product does at the molecular level
  • identical protein binding
  • protein binding
  • RNA binding
  • rRNA (guanosine-2'-O-)-methyltransferase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.