Cd68 Gene Summary [Rat]
Involved in autocrine signaling and response to ethanol. Predicted to be located in lysosome. Predicted to be active in late endosome membrane; lysosomal membrane; and plasma membrane. Biomarker of metabolic dysfunction and alcohol associated liver disease and metabolic dysfunction-associated steatohepatitis. Orthologous to human CD68 (CD68 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd68 |
| Official Name | Cd68 molecule [Source:RGD Symbol;Acc:1305970] |
| Ensembl ID | ENSRNOG00000037563 |
| Bio databases IDs | |
| Aliases | Cd68 molecule |
| Synonyms | CD68 ANTIGEN, CD68 molecule, ED-1, GP110, LAMP4, SCARD1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd68 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysosome-associated membrane glycoprotein (Lamp)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- kidney disease
- rheumatoid arthritis
- organismal death
- lung adenocarcinoma formation
- metabolic syndrome X
- oligoarticular juvenile idiopathic arthritis
- Alzheimer disease
- obesity
- Huntington disease
- Erdheim-Chester disease
regulates
- LDL
role in cell
- function
- abnormal morphology
- binding
- removal
- response
- antigen presentation by
- entrance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- endosomal membrane fractions
- Cytoplasm
- cell surface
- cell periphery
- cellular membrane
- endosomes
- lysosome
- secretory granule membrane
- granules
- lysosome membrane
- lysosomal compartment
- endosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd68 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of protein localization to organelle
- cellular response to nutrient levels
- inflammatory response to antigenic stimulus
- cellular response to lipopolysaccharide
- negative regulation of dendritic cell antigen processing and presentation
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- membrane
- azurophil granule membrane
- plasma membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding