Dysf Gene Summary [Rat]
Predicted to enable calcium ion binding activity; calcium-dependent phospholipid binding activity; and tubulin binding activity. Predicted to be involved in T-tubule organization; plasma membrane repair; and vesicle fusion. Predicted to act upstream of or within several processes, including myeloid cell activation involved in immune response; negative regulation of macromolecule metabolic process; and regulation of calcium ion transport. Located in cytoplasm. Human ortholog(s) of this gene implicated in Miyoshi muscular dystrophy 1; autosomal recessive limb-girdle muscular dystrophy type 2B; distal myopathy with anterior tibial onset; and muscular dystrophy. Orthologous to human DYSF (dysferlin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dysf |
| Official Name | dysferlin [Source:RGD Symbol;Acc:1311023] |
| Ensembl ID | ENSRNOG00000032788 |
| Bio databases IDs | |
| Aliases | dysferlin |
| Synonyms | 2310004N10Rik, D6Pas3, Dysferlin, FER1L1, LGMD2B, LGMDR2, MMD1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dysf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- calcium ion binding
- calcium-dependent phospholipid binding
- protein binding
- microtubule binding
- Dysferlin domain, N-terminal region
- FerA (NUC095) domain
- cytoplasmic domain
- FerI (NUC094) domain
- alpha-tubulin binding
- Protein kinase C conserved region 2 (CalB)
- C2 domain
- FerB (NUC096) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- dysferlinopathy
- Miyoshi myopathy
- limb-girdle muscular dystrophy type 2B
- limb-girdle muscular dystrophy type 2
- early missed abortion
- limb-girdle muscular dystrophy type 1c
- early onset cardiomyopathy
- septic shock
- endomysial fibrosis
role in cell
- expression in
- quantity
- size
- activation
- proliferation
- repair in
- differentiation
- development
- damage
- disruption
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoplasmic vesicle membrane
- intracellular network
- Cytoplasm
- cell surface
- cell periphery
- membrane surface
- cellular membrane
- focal adhesions
- Nucleus
- endosomes
- vesicles
- centrosome
- Golgi Apparatus
- microtubules
- cell-cell contacts
- granules
- microdomains
- sarcolemma
- early endosomes
- late endosomes
- cytoplasmic vesicles
- endocytotic vesicle
- transverse tubules
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dysf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- monocyte activation involved in immune response
- macrophage activation involved in immune response
- negative regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- T-tubule
- endocytic vesicle
- cytoplasmic vesicle membrane
- early endosome
- extracellular vesicular exosome
- endosome
- centriolar satellite
- sarcolemma
- late endosome
- synaptic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- phospholipid binding
- calcium-dependent phospholipid binding