Hcls1 Gene Summary [Rat]
Predicted to enable several functions, including SH3 domain binding activity; actin filament binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including granulocyte colony-stimulating factor signaling pathway; positive regulation of myeloid leukocyte differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleus. Predicted to be part of transcription regulator complex. Predicted to be active in cortical actin cytoskeleton; plasma membrane; and site of polarized growth. Predicted to colocalize with actin filament. Orthologous to human HCLS1 (hematopoietic cell-specific Lyn substrate 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hcls1 |
| Official Name | hematopoietic cell specific Lyn substrate 1 [Source:RGD Symbol;Acc:1304754] |
| Ensembl ID | ENSRNOG00000038881 |
| Bio databases IDs | |
| Aliases | hematopoietic cell specific Lyn substrate 1 |
| Synonyms | CTTNL, haematopoietic cell-specific Lyn substrate 1, haematopoietic specific protein 1, hematopoietic cell-specific Lyn substrate 1, Hematopoietic specific protein 1, HS1, LCKBP1, LOC102552892, LYN SUBSTRATE 1, p75 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hcls1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- DNA binding domain
- protein binding activity, bridging
- transcription factor binding
- coiled-coil domain
- protein binding
- Repeat in HS1/Cortactin
- proline rich domain
- SH3-domain binding
- Src Homology 3 domain superfamily
- actin filament binding
- F-actin binding domain
- binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
- androgenic alopecia
- osteoarthritis
- insulin-dependent diabetes mellitus
- bleeding
- metastatic colorectal cancer
- thrombosis
- rheumatoid arthritis
- familial Waldenstrom macroglobulinemia
role in cell
- differentiation
- expression in
- apoptosis
- migration
- proliferation
- chemotaxis
- branching
- signal transduction in
- dynamics
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell periphery
- perinuclear region
- Plasma Membrane
- Mitochondria
- immunological synapses
- cytosol
- microsome
- membrane ruffles
- membrane rafts
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hcls1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- granulocyte colony-stimulating factor signaling pathway
- positive regulation of protein import into nucleus
- signal transduction
- positive regulation of cell proliferation
- regulation of transcription, DNA-dependent
- actin filament organization
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of transcription from RNA polymerase II promoter
- response to hormone stimulus
- negative regulation of transcription from RNA polymerase II promoter
- regulation of actin filament polymerization
- nuclear transport
- positive regulation of granulocyte differentiation
- erythrocyte differentiation
- negative regulation of leukocyte apoptotic process
- positive regulation of macrophage differentiation
- cellular response to cytokine stimulus
- positive regulation of protein kinase B signaling cascade
- intracellular signal transduction
- positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- endocytic vesicle
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein kinase binding
- protein binding
- signaling adaptor activity
- SH3 domain binding