Acsm2 Gene Summary [Rat]
Predicted to enable benzoate-CoA ligase activity; decanoate-CoA ligase activity; and long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in mitochondrial matrix. Orthologous to human ACSM1 (acyl-CoA synthetase medium chain family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acsm2 |
| Official Name | acyl-CoA synthetase medium-chain family member 2 [Source:RGD Symbol;Acc:708383] |
| Ensembl ID | ENSRNOG00000042084 |
| Bio databases IDs | |
| Aliases | acyl-CoA synthetase medium-chain family member 2 |
| Synonyms | Acas3, acyl-CoA synthetase medium-chain family member 1, BUCS1, Macs, MACS1, Medium-Chain Acyl-Coa Synthetase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acsm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetate--CoA ligase
- Adenylate forming domain, Class I superfamily
- enzyme
- benzoate-CoA ligase
- protein binding
- fatty-acid ligase
- long-chain-fatty-acid-CoA ligase
- butyrate-CoA ligase
- benzoate-CoA ligase family
- AMP-binding enzyme
- CoA-ligase
- acyl-CoA ligase (AMP-forming), exosortase A-associated
- AMP-binding enzyme C-terminal domain
- amino acid adenylation domain
Pathways
Biological processes and signaling networks where the Acsm2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acsm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- butyrate metabolic process
- acyl-CoA metabolic process
- long-chain fatty acid metabolic process
- energy derivation by oxidation of organic compounds
- fatty acid oxidation
- xenobiotic metabolic process
- fatty acid biosynthetic process
- benzoate metabolic process
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrial matrix
- blood microparticle
Molecular Function
What the gene product does at the molecular level
- medium-chain fatty acid-CoA ligase activity
- GTP binding
- ATP binding
- CoA-ligase activity
- protein binding
- benzoate-CoA ligase activity
- metal ion binding
- fatty-acyl-CoA synthase activity
- long-chain fatty acid-CoA ligase activity
- fatty acid ligase activity