Gbp5 Gene Summary [Rat]
Predicted to enable several functions, including GTP binding activity; GTPase activity; and protein homodimerization activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of defense response. Predicted to act upstream of or within response to bacterium. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi membrane; cytoplasmic vesicle; and symbiont cell surface. Orthologous to human GBP5 (guanylate binding protein 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gbp5 |
| Official Name | guanylate binding protein 5 [Source:RGD Symbol;Acc:1311040] |
| Ensembl ID | ENSRNOG00000032240 |
| Bio databases IDs | |
| Aliases | guanylate binding protein 5 |
| Synonyms | 5330409J06Rik, Gbp5a, guanylate binding protein 5, Ifn-induced guanylate-binding protein 5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gbp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- Vacuolar (H+)-ATPase G subunit
- GTPase regulator
- Guanylate-binding protein, N-terminal domain
- small monomeric GTPase
- protein homodimerization
- GTPase
- enzyme
- protein binding
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- Guanylate-binding protein, C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatitis
- osteopenia
- hepatic injury
- dextran sodium sulfate-induced colitis
role in cell
- response
- apoptosis
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
- Golgi membrane
- cytoplasmic vesicles