Eef1a1 Gene Summary [Rat]
Enables heterocyclic compound binding activity; identical protein binding activity; and mRNA binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; negative regulation of reactive oxygen species biosynthetic process; and regulation of postsynaptic specialization assembly. Is active in GABA-ergic synapse and postsynapse. Orthologous to several human genes including EEF1A1 (eukaryotic translation elongation factor 1 alpha 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eef1a1 |
| Official Name | eukaryotic translation elongation factor 1 alpha 1 [Source:RGD Symbol;Acc:67387] |
| Ensembl ID | ENSRNOG00000009439 |
| Bio databases IDs | |
| Aliases | eukaryotic translation elongation factor 1 alpha 1 |
| Synonyms | EE1A1, EEF-1, EEF1A, Eef1a2, Eef1a2l1, eEf1alpha, Eef-tu, EF-1, EF1A, EF1A1, EF1A-LIKE, EF-1-alpha-1, EF-1-α-1, EF-Tu, Eif1a1, ELONGATION FACTOR 1 alpha, ELONGATION FACTOR 1 α, Elongation factor Tu, eukaryotic elongation factor 1 α 1, eukaryotic translation elongation factor 1 alpha 1, eukaryotic translation elongation factor 1 α 1, GRAF-1EF, LENG7, prostate tumour inducing gene-1, PTI1, SI, TRANSLATION ELONGATION FACTOR 1 alpha 1, TRANSLATION ELONGATION FACTOR 1 α 1, α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eef1a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- protein kinase binding
- calmodulin binding
- translation elongation factor
- mRNA binding
- Elongation factor Tu C-terminal domain
- GTPase
- protein binding
- Elongation factor Tu domain 2
- identical protein binding
- translation regulator
- phosphorylation site
- GTP binding
- Domain III of Elongation factor (EF) Tu (EF-TU) and related proteins
- sulfate adenylyltransferase, large subunit
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- kinase binding
- binding protein
- small GTP-binding protein domain
- translation elongation factor TU
- translation elongation factor EF-1 alpha
- kinase activator
- Elongation factor Tu GTP binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- liver cancer
- colorectal cancer
- organismal death
- neoplastic cell transformation
- Alzheimer disease
- metastasis
- androgenic alopecia
- atopic dermatitis
- amyotrophic lateral sclerosis
role in cell
- cell death
- expression in
- apoptosis
- phosphorylation in
- proliferation
- formation
- binding
- migration
- cell cycle progression
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- cortical actin cytoskeleton
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- perinuclear region
- postsynaptic region
- cellular membrane
- filamentous network
- ribosome
- Nucleus
- Plasma Membrane
- microtubules
- cytosol
- membrane ruffles
- lysosome membrane
- inner nuclear membrane
- nucleoli
- synapse
- perikaryon
- dendrites
- postsynaptic density
- inhibitory synapse
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eef1a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to epidermal growth factor stimulus
- regulation of D-erythro-sphingosine kinase activity
- translational elongation
- translation
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- ribosome
- nucleolus
- extracellular region
- eukaryotic translation elongation factor 1 complex
- plasma membrane
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- ruffle membrane
- secretory granule lumen
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- protein binding
- RNA binding
- translation elongation factor activity
- GTPase activity
- tRNA binding
- kinase binding
- binding, bridging