Capn2 Gene Summary [Rat]
Enables calcium ion binding activity; cytoskeletal protein binding activity; and enzyme binding activity. Contributes to calcium-dependent cysteine-type endopeptidase activity. Involved in several processes, including cellular response to interferon-beta; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of myoblast fusion. Located in several cellular components, including external side of plasma membrane; focal adhesion; and neuronal cell body. Biomarker of hypertrophic cardiomyopathy; sciatic neuropathy; and traumatic brain injury. Orthologous to human CAPN2 (calpain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Capn2 |
| Official Name | calpain 2 [Source:RGD Symbol;Acc:2268] |
| Ensembl ID | ENSRNOG00000034015 |
| Bio databases IDs | |
| Aliases | calpain 2 |
| Synonyms | CALCIUM ACTIVATED NEUTRAL PROTEINASE, CALP80, Calpain2, calpain II, CANP2, CANPL2, CANPml, Capa-2, M80, M-CALPAIN, m-calpin, mCANP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Capn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- regulatory domain
- calpain
- catalytic domain
- peptidase
- calcium ion binding
- enzyme binding
- EFh
- calcium binding loop
- protein binding
- CysPc
- The penta-EF hand (PEF) family
- protease domain
- Calpain family cysteine protease
- cysteine-type peptidase
- binding protein
- cytoskeletal protein binding
- Calpain_III
Pathways
Biological processes and signaling networks where the Capn2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Amyotrophic Lateral Sclerosis Signaling
- Apoptosis Signaling
- Calcium-induced T Lymphocyte Apoptosis
- Cellular Effects of Sildenafil (Viagra)
- Huntington's Disease Signaling
- Integrin Signaling
- Mitochondrial Dysfunction
- nNOS Signaling in Neurons
- Regulation of Cellular Mechanics by Calpain Protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- non-insulin-dependent diabetes mellitus
- organismal death
- metastasis
- schizophrenia
- spondylarthritis
- hepatocellular carcinoma
- cold thyroid nodule
role in cell
- proliferation
- migration
- expression in
- apoptosis
- binding in
- survival
- cell death
- phosphorylation in
- activation in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cortical actin cytoskeleton
- postsynaptic region
- focal adhesions
- podosomes
- Nucleus
- Plasma Membrane
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- cytosol
- reticular perinuclear compartment
- plasma membrane extracellular face
- neurites
- membrane rafts
- cellular protrusions
- pseudopodia
- chromatin
- perikaryon
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Capn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myoblast fusion
- female pregnancy
- response to hydrogen peroxide
- response to mechanical stimulus
- cellular response to amino acid stimulus
- response to hypoxia
- cellular response to lipopolysaccharide
- regulation of cytoskeleton organization
- blastocyst development
- behavioral response to pain
- proteolysis
- positive regulation of phosphatidylcholine biosynthetic process
- positive regulation of cardiac muscle cell apoptotic process
- regulation of interleukin-6 production
- protein autoprocessing
- proteolysis involved in cellular protein catabolic process
- cellular response to interferon-beta
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- endoplasmic reticulum
- Golgi apparatus
- neuronal cell body
- chromatin
- plasma membrane
- lysosome
- nucleus
- dendrite
- extracellular vesicular exosome
- perinuclear endoplasmic reticulum
- focal adhesion
- cytoplasm
- membrane raft
- cytosol
- pseudopodium
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- cysteine-type peptidase activity
- calcium-dependent cysteine-type endopeptidase activity
- cytoskeletal protein binding
- enzyme binding