Nipa1 Gene Summary [Rat]
Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be located in early endosome and plasma membrane. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 6. Orthologous to human NIPA1 (NIPA magnesium transporter 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nipa1 |
| Official Name | NIPA magnesium transporter 1 [Source:RGD Symbol;Acc:1305401] |
| Ensembl ID | ENSRNOG00000042702 |
| Bio databases IDs | |
| Aliases | NIPA magnesium transporter 1 |
| Synonyms | 1110027G09RIK, A830014A18Rik, AC270126.1, FSP3, NIPA magnesium transporter 1, non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human), SLC56A1, SLC57A1, SPG6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nipa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EamA-like transporter family
- protein binding
- magnesium ion transporter
- Magnesium transporter NIPA
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nipa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- magnesium ion transport
Cellular Component
Where in the cell the gene product is active
- early endosome
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- magnesium ion transmembrane transporter activity