Cckar Gene Summary [Rat]
Enables cholecystokinin receptor activity. Involved in several processes, including positive regulation of somatostatin secretion; reduction of food intake in response to dietary excess; and regulation of metal ion transport. Located in endosome and terminal bouton. Used to study obesity and type 2 diabetes mellitus. Biomarker of pancreatic cancer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cckar |
| Official Name | cholecystokinin A receptor [Source:RGD Symbol;Acc:2289] |
| Ensembl ID | ENSRNOG00000043124 |
| Bio databases IDs | |
| Aliases | cholecystokinin A receptor |
| Synonyms | CCK-1R, CCK1 receptor, CCK-A, CCKA Receptor, Ccka receptors, Cckr, CCKRA, cholecystokinin A receptor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cckar often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- cholecystokinin receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the Cckar gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- pancreatic neoplasia
- irritable bowel syndrome
- epithelial cancer
- schizophrenia
- gastroesophageal junction adenocarcinoma
- esophagogastric junction cancer
- hyperactive behavior
role in cell
- phosphorylation in
- expression in
- growth
- migration
- number
- activation in
- abnormal morphology
- hypertrophy
- elevation in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- endosomes
- cytosol
- nucleoplasm
- perikaryon
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cckar gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- forebrain development
- G-protein coupled receptor signaling pathway
- regulation of hormone secretion
- axonogenesis
- cellular response to hormone stimulus
- phospholipase C-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- peptide binding
- peptide hormone binding
- cholecystokinin receptor activity