CCKAR
CCKAR Gene Summary
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CCKAR |
| Official Name | cholecystokinin A receptor [Source:HGNC Symbol;Acc:HGNC:1570] |
| Ensembl ID | ENSG00000163394 |
| Bio databases IDs | |
| Aliases | cholecystokinin A receptor |
| Synonyms | CCK-1R,CCK1 receptor,CCK-A,CCKA Receptor,Ccka receptors,Cckr,CCKRA,cholecystokinin A receptor |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- cholecystokinin receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the CCKAR gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CCKBR
- IQM 95333
- BDZ-1
- SR-27,897
- Jmv 180
- CCK
- tarazepide
- lintitript
- T-0632
- dexloxiglumide
disease
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- pancreatic neoplasia
- irritable bowel syndrome
- epithelial cancer
- schizophrenia
- gastroesophageal junction adenocarcinoma
- esophagogastric junction cancer
- hyperactive behavior
regulated by
- NFkB (complex)
- NKX2-1
- estrogen
- CCK
- tetrachlorodibenzodioxin
- IL1B
- BHLHA15
- beta-estradiol
- sphingolipid
- GI181771X
regulates
- Ca2+
- amylase
- AKT
- PI3K (complex)
- insulin
- SST
- MAPK
- inositol 1-phosphate
- cholesterol
- EGR1
role in cell
- phosphorylation in
- expression in
- growth
- migration
- number
- activation in
- abnormal morphology
- hypertrophy
- elevation in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- endosomes
- cytosol
- nucleoplasm
- perikaryon
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CCKAR gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- neuron migration
- forebrain development
- G-protein coupled receptor signaling pathway
- regulation of hormone secretion
- axonogenesis
- cellular response to hormone stimulus
- phospholipase C-activating G-protein coupled receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- membrane
- cytosol
- plasma membrane
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- peptide binding
- peptide hormone binding
- cholecystokinin receptor activity