Sst Gene Summary [Rat]
Predicted to enable identical protein binding activity and receptor ligand activity. Involved in several processes, including hyperosmotic response; response to acidic pH; and response to steroid hormone. Located in extracellular space and neuronal cell body. Is active in neuronal dense core vesicle. Biomarker of gastric ulcer; hypertension; and vascular dementia. Orthologous to human SST (somatostatin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sst |
| Official Name | somatostatin [Source:RGD Symbol;Acc:3761] |
| Ensembl ID | ENSRNOG00000001837 |
| Bio databases IDs | |
| Aliases | somatostatin |
| Synonyms | Preprosomatostatin, prosomatostatin, SMST, SOM, somatostatin, SRIF, Srih, SS, SST1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sst often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Somatostatin/Cortistatin family
- hormone
- receptor agonist activity
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Sst gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- benign neoplasia
- colorectal cancer
- Huntington disease
- schizophrenia
- androgenic alopecia
- experimentally induced seizure
- psychosis
- epileptic seizure
- hyperchlorhydria
role in cell
- activation in
- migration
- expression in
- apoptosis
- accumulation in
- phosphorylation in
- proliferation
- inhibition
- cell cycle progression
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- mossy fiber band
- peptidergic fiber
- Cytoplasm
- perinuclear Golgi regions
- cell surface
- cellular membrane
- Nucleus
- Plasma Membrane
- cytosol
- synapse
- secretory granules
- membrane processes
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sst gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- negative regulation of cell proliferation
- response to amino acid stimulus
- cell-cell signaling
- digestion
- synaptic transmission
- response to nutrient
- cell surface receptor signaling pathway
- response to xenobiotic stimulus
- response to steroid hormone stimulus
- hyperosmotic response
- induction of apoptosis by hormones
- response to acidity
- regulation of cell migration
- response to organic nitrogen
Cellular Component
Where in the cell the gene product is active
- extracellular space
- neuronal cell body
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- hormone activity