Nfs1 Gene Summary [Rat]
Predicted to enable cysteine desulfurase activity and protein homodimerization activity. Predicted to be involved in iron-sulfur cluster assembly and molybdopterin cofactor metabolic process. Predicted to be located in centrosome; mitochondrial matrix; and nucleoplasm. Predicted to be part of mitochondrial [2Fe-2S] assembly complex. Predicted to be active in cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 52. Orthologous to human NFS1 (NFS1 cysteine desulfurase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfs1 |
| Official Name | NFS1 cysteine desulfurase [Source:RGD Symbol;Acc:620912] |
| Ensembl ID | ENSRNOG00000045686 |
| Bio databases IDs | |
| Aliases | NFS1 cysteine desulfurase |
| Synonyms | COXPD52, HUSSY-08, IscS, m-Nfs1, m-Nfsl, NFS1 cysteine desulfurase, NIFS, Nifs-like protein precursor, nitrogen fixation gene 1 (S. cerevisiae) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nfs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine desulfurase IscS
- Aminotransferase class-V
- cysteine desulfurases, SufSfamily
- cysteine desulfurase NifS
- cysteine desulfurase DndA
- cysteine desulfurase
- protein homodimerization
- AAT_I
- Beta-eliminating lyase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Nfs1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- glioblastoma cancer
- combined oxidative phosphorylation deficiency 52
- Alzheimer disease
- coronary artery disease
- non-melanoma skin cancer
regulates
- succinate dehydrogenase
- molybdenum cofactor complex
- L-cysteine
- iron-sulfur
- ACO1
- aconitase
role in cell
- growth
- morphology
- survival
- josamycin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nfs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- [2Fe-2S] cluster assembly
- iron incorporation into metallo-sulfur cluster
- [4Fe-4S] cluster assembly
- Mo-molybdopterin cofactor biosynthetic process
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- mitochondrial matrix
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cysteine desulfurase activity
- pyridoxal phosphate binding
- protein homodimerization activity
- protein binding
- metal ion binding
- iron-sulfur cluster binding