Gria1 Gene Summary [Rat]
Enables several functions, including enzyme binding activity; signaling receptor binding activity; and transmitter-gated monoatomic ion channel activity. Involved in several processes, including central nervous system development; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; endosome membrane; and neuronal cell body membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Used to study cocaine dependence; hyperhomocysteinemia; morphine dependence; and withdrawal disorder. Biomarker of several diseases, including alcohol use disorder; amphetamine abuse; brain disease (multiple); cocaine abuse; and drug dependence (multiple). Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 67; autosomal recessive intellectual developmental disorder 76; and epilepsy. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gria1 |
| Official Name | glutamate ionotropic receptor AMPA type subunit 1 [Source:RGD Symbol;Acc:621531] |
| Ensembl ID | ENSRNOG00000045816 |
| Bio databases IDs | |
| Aliases | glutamate ionotropic receptor AMPA type subunit 1 |
| Synonyms | 2900051M01Rik, Ampa1, GLR1, GluA1, GLUH1, GLUR1, GluR1alpha, GLURA, gluR-K1, glutamate ionotropic receptor AMPA type subunit 1, glutamate receptor, ionotropic, AMPA1 (alpha 1), glutamate receptor, ionotropic, AMPA1 (α 1), HBGR1, HIPA1, LOC691178, MRD67, MRT76 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gria1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- identical protein binding
- ion channel
- myosin binding
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor
- cytoplasmic domain
- ligand-binding domain
- Type 1 periplasmic binding fold superfamily
- Type 2 periplasmic binding fold superfamily
- tail domain
- Receptor family ligand binding region
- protein kinase A binding
- protein kinase binding
- channel/pore class transporter
- calcium channel
- Ligated ion channel L-glutamate- and glycine-binding site
- ionotropic glutamate receptor
- enzyme binding
- protein domain specific binding
- beta-amyloid binding
- extracellular ligand-gated ion channel
- protein binding
- receptor binding
- ionotropic glutamate receptor binding
- immunoglobulin binding
- PDZ-domain binding
- phosphorylation site
- neurotransmitter receptor
- adenylate cyclase binding
- ligand-gated ion channel
- cytosolic tail domain
- cation channel
Pathways
Biological processes and signaling networks where the Gria1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Calcium Signaling
- Circadian Rhythm Signaling
- CREB Signaling in Neurons
- Gap Junction Signaling
- Glutamate Receptor Signaling
- Neuroinflammation Signaling Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Parkinson's Signaling Pathway
- RAR Activation
- Synaptic Long Term Depression
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- Parkinson disease
- disorder of coronary artery
- stroke
- COVID-19
- autosomal recessive intellectual developmental disorder type 76
- perioperative pain
- pain
- epilepsy
- schizophrenia
role in cell
- phosphorylation in
- expression in
- proliferation
- plasticity
- activation
- long term synaptic depression
- assembly
- action potential
- long-term potentiation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- soluble fraction
- postsynaptic density (PSD) fractions
- detergent-insoluble fractions
- detergent-soluble membrane fractions
- membrane fraction
- synaptic vesicle membrane
- glutaminergic synapse
- endocytic vesicle membrane
- cytoskeleton
- organelle
- Cytoplasm
- presynaptic regions
- cell surface
- Extracellular Space
- cell periphery
- somatodendritic region
- postsynaptic region
- intracellular membranes
- membrane surface
- cellular membrane
- vesicles
- Endoplasmic Reticulum
- intercellular junctions
- cytosol
- endoplasmic reticulum membrane
- microsome
- plasma membrane extracellular face
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- endosomal membrane
- nuclear rim
- dendritic spines
- synaptic vesicles
- neuromuscular junctions
- growth cone
- neurites
- dendrite initial segments
- synaptosomes
- synapse
- recycling endosomes
- early endosomes
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- axospinous synapses
- axodendritic synapses
- excitatory synapses
- dendritic shafts
- clathrin-coated vesicles
- detergent-soluble fraction
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gria1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to xenobiotic stimulus
- spinal cord development
- cellular response to amino acid stimulus
- response to arsenic-containing substance
- cellular response to peptide hormone stimulus
- cellular response to dsRNA
- long-term synaptic potentiation
- long term synaptic depression
- response to electrical stimulus
- calcium-mediated signaling
- ionotropic glutamate receptor signaling pathway
- cellular response to amine stimulus
- regulation of action potential in neuron
- positive regulation of membrane potential
- regulation of postsynaptic membrane potential
- response to fungicide
- signal transduction
- ion transmembrane transport
- response to cocaine
- synaptic transmission
- cerebral cortex development
- long-term memory
- synapse assembly
- positive regulation of gene expression
- cellular response to ammonium ion
- response to lithium ion
- response to estradiol stimulus
- regulation of synaptic transmission
- receptor internalization
- regulation of receptor recycling
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendritic spine membrane
- neuronal cell body membrane
- neuronal cell body
- endoplasmic reticulum membrane
- dendrite
- postsynaptic membrane
- dendritic shaft
- dendritic spine
- neuromuscular junction
- endocytic vesicle membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
- axonal spine
- neuron spine
- excitatory synapse
- synaptic membrane
- presynaptic active zone membrane
- plasma membrane
- cell surface
- early endosome membrane
- cell-cell junction
- ER to Golgi transport vesicle membrane
- recycling endosome
- synaptic vesicle membrane
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- glutamate receptor binding
- identical protein binding
- G-protein beta-subunit binding
- glutamate receptor activity
- glutamate-gated calcium ion channel activity
- adenylate cyclase binding
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
- beta-amyloid binding
- scaffold protein binding
- protein binding
- G-protein alpha-subunit binding
- PDZ domain binding
- small GTPase binding
- immunoglobulin binding
- beta-2 adrenergic receptor binding
- myosin V binding
- protein kinase A binding