Pgap3 Gene Summary [Rat]
Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 4. Orthologous to human PGAP3 (post-GPI attachment to proteins phospholipase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgap3 |
| Official Name | post-GPI attachment to proteins phospholipase 3 [Source:RGD Symbol;Acc:1592386] |
| Ensembl ID | ENSRNOG00000046143 |
| Bio databases IDs | |
| Aliases | post-GPI attachment to proteins phospholipase 3 |
| Synonyms | AGLA546, CAB2, D430035D22Rik, hCOS16, PERLD1, post-GPI attachment to proteins 3, post-GPI attachment to proteins phospholipase 3, PP1498 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pgap3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- Per1-like family
- ester bond hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inflammatory bowel disease
- cardiovascular disorder
- hyperphosphatasia with mental retardation syndrome type 4
- hereditary disorder
- breast cancer
- Crohn disease
- asthma
- paralysis
- congestive heart failure
- insulin-dependent diabetes mellitus
regulates
- Immunoglobulin
- double-stranded DNA
role in cell
- function
- proliferation
- abnormal morphology
- differentiation
- engulfment by
- phagocytosis by
- Th2 immune response
- engulfment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pgap3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- GPI anchor metabolic process
- GPI anchor biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, acting on ester bonds
- protein binding