TSPAN15 Gene Summary [Human]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TSPAN15 |
| Official Name | tetraspanin 15 [Source:HGNC Symbol;Acc:HGNC:23298] |
| Ensembl ID | ENSG00000099282 |
| Bio databases IDs | |
| Aliases | tetraspanin 15 |
| Synonyms | 1110036D12RIK, 2700063A19Rik, NET-7, tetraspanin 15, TM4SF15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TSPAN15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- breast cancer
- pulmonary embolism
- pulmonary infarction
- venous thromboembolism
- deep vein thrombosis
- thromboembolism
- early missed abortion
- heart disease
role in cell
- expression in
- transmigration
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- tetraspanin-enriched microdomain
- cell junction
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- cytosol
- endoplasmic reticulum lumen
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TSPAN15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Notch signaling pathway
- regulation of membrane protein ectodomain proteolysis
- protein maturation
- negative regulation of Notch signaling pathway
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- endoplasmic reticulum lumen
- nuclear body
- intracellular membrane-bounded organelle
- cell junction
- cytosol
- plasma membrane
- tetraspanin-enriched microdomain
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme binding