Pnpo Gene Summary [Rat]
Enables pyridoxamine phosphate oxidase activity. Predicted to be involved in pyridoxal phosphate biosynthetic process and pyridoxamine metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in pyridoxamine 5'-phosphate oxidase deficiency. Orthologous to human PNPO (pyridoxamine 5'-phosphate oxidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pnpo |
| Official Name | pyridoxamine 5'-phosphate oxidase [Source:RGD Symbol;Acc:621456] |
| Ensembl ID | ENSRNOG00000046493 |
| Bio databases IDs | |
| Aliases | pyridoxamine 5'-phosphate oxidase |
| Synonyms | AI415282, HEL-S-302, PDXPO, pyridoxamine 5'-phosphate oxidase, pyridoxine 5'-phosphate oxidase, U91561 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pnpo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pyridoxamine-phosphate oxidase
- Pyridoxine 5'-phosphate (PNP) oxidase-like and flavin reductase-like proteins
- Pyridoxamine 5'-phosphate oxidase
- pyridoxal phosphate binding
- FMN binding
- protein homodimerization
- enzyme
- protein binding
- Pyridoxine 5'-phosphate oxidase C-terminal dimerization region
- PLN02918
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pnpo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyridoxal phosphate biosynthetic process
- pyridoxine biosynthetic process
- pyridoxamine metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- pyridoxamine-phosphate oxidase activity
- pyridoxal phosphate binding
- protein binding
- protein homodimerization activity
- FMN binding