Il36g Gene Summary [Rat]
Predicted to enable cytokine activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; cytokine-mediated signaling pathway; and inflammatory response. Predicted to act upstream of or within negative regulation of myoblast differentiation; negative regulation of myoblast fusion; and positive regulation of interleukin-6 production. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in extracellular space. Orthologous to human IL36G (interleukin 36 gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il36g |
| Official Name | interleukin 36, gamma [Source:RGD Symbol;Acc:1563019] |
| Ensembl ID | ENSRNOG00000005701 |
| Bio databases IDs | |
| Aliases | interleukin 36, gamma |
| Synonyms | If36g, IL1E, IL-1F9, IL-1H1, IL-1RP2, IL-36gamma, interleukin 36G, interleukin 36 gamma, interleukin 36, gamma, interleukin 36 γ, interleukin 36, γ, RGD1563019 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il36g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine
- beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines
Pathways
Biological processes and signaling networks where the Il36g gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Agranulocyte Adhesion and Diapedesis
- Atherosclerosis Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- Erythropoietin Signaling
- FXR/RXR Activation
- Graft-versus-Host Disease Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- NF-κB Signaling
- p38 MAPK Signaling
- PPAR Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Systemic Lupus Erythematosus Signaling
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
- acne
- paralysis
- inflammatory bowel disease
- congenital erythroderma with palmoplantar keratoderma, hypotrichosis, and hyper-IgE
- pruritus
- psoriasis
- contact hypersensitivity
- psoriatic lesion
- colitis
role in cell
- expression in
- activation in
- apoptosis
- proliferation
- survival
- killing
- autophagy in
- activation
- production in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il36g gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- inflammatory response to antigenic stimulus
- innate immune response
- positive regulation of gene expression
- cytokine-mediated signaling pathway
- cell-cell signaling
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
- extracellular region
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cytokine activity
- interleukin-1 receptor binding