Agtrap Gene Summary [Rat]
Predicted to enable angiotensin type II receptor activity and identical protein binding activity. Involved in response to hypoxia. Predicted to be located in Golgi apparatus and cell cortex. Predicted to be active in plasma membrane. Biomarker of hypertension. Orthologous to human AGTRAP (angiotensin II receptor associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agtrap |
| Official Name | angiotensin II receptor-associated protein [Source:RGD Symbol;Acc:1359346] |
| Ensembl ID | ENSRNOG00000008619 |
| Bio databases IDs | |
| Aliases | angiotensin II receptor-associated protein |
| Synonyms | 3300002E14RIK, angiotensin II receptor-associated protein, angiotensin II, type I receptor-associated protein, AT1R, ATRAP, D4Wsu124e |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Agtrap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- angiotensin type II receptor
- Angiotensin II, type I receptor-associated protein (AGTRAP)
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Agtrap gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- insulin resistance
- atrial fibrillation
- organismal death
- hypertension
- breast cancer
- wasting
- hyperalbuminemia
- septic shock
- laser induced choroidal neovascularization
role in cell
- expression in
- production in
- cell viability
- activation in
- proliferation
- migration
- stabilization in
- quantity
- phosphorylation in
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- cell cortex
- endosomes
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Agtrap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hypoxia
- angiotensin-mediated signaling pathway
- regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- cell cortex
- Golgi apparatus
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- angiotensin type II receptor activity